منابع مشابه
Teratogenic effect of carbamazepine.
A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy. The infant had dysmorphic features and was physically and mentally retarded. We consider that the malformations were the result of the maternal treatment with carbamazepine.
متن کاملTeratogenic effect of Carbamazepine use during pregnancy in the mice.
Carbamazepine use is the first choice of antiepileptic drugs among epileptic pregnant females. There are many inconclusive studies regard the safety of carbamazepine use during pregnancy. This study aims to investigate the morphological and histopathological teratogenic effects of carbamazepine use during pregnancy. The healthy pregnant females mice divided into equal five groups (each n=20). T...
متن کاملTeratogenic Effects of Carbamazepine in Mice
OBJECTIVES The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. MATERIALS AND METHODS Mature female and male BALB/c mice (25-30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated groups (CBZ 450 mg/kg and 600 mg/kg) were fed on medicinal diet. The dams in the control group were ...
متن کاملTeratogenic effects of carbamazepine on embryonic eye development in pregnant mice.
BACKGROUND Carbamazepine is an antiepileptic drug used widely for the treatment of epileptic seizures and neuropathic pain. Several malformations in humans, mainly neural tube defects, have been reported as a consequence of its use during pregnancy. The association between maternal use of carbamazepine and congenital eye malformations is not very well understood. OBJECTIVE The purpose of this...
متن کاملTeratogenic effect of hydrosalpinx fluid in humans?
We read with great interest the manuscript by Chan et al. (2003) examining the teratogenicity of hydrosalpinx ¯uid (HF) using a whole rate embryo culture model. Mechanisms of HF formation and its effects on IVF and embryo transfer outcome have been recently reviewed (Ajonuma et al., 2002). Previous studies were conducted during early embryo development when HF that re¯uxed into the uterine cavi...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1991
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.66.5.641